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Autologous blood cell transplantation versus HLA-identical sibling transplantation for acute myeloid leukemia in first complete remission: a registry study from the Center for International Blood and Marrow Transplantation Research

Identifieur interne : 004819 ( Main/Exploration ); précédent : 004818; suivant : 004820

Autologous blood cell transplantation versus HLA-identical sibling transplantation for acute myeloid leukemia in first complete remission: a registry study from the Center for International Blood and Marrow Transplantation Research

Auteurs : Armand Keating [Canada] ; Gisela Dasilva [Brésil] ; Waleska S. Pérez [États-Unis] ; Vikas Gupta [Canada] ; Corey S. Cutler [États-Unis] ; Karen K. Ballen [États-Unis] ; Mitchell S. Cairo [États-Unis] ; Bruce M. Camitta [États-Unis] ; Richard E. Champlin [États-Unis] ; James L. Gajewski [États-Unis] ; Hillard M. Lazarus [États-Unis] ; Michael Lill [États-Unis] ; David I. Marks [Royaume-Uni] ; Chadi Nabhan [États-Unis] ; Gary J. Schiller [États-Unis] ; Gerald Socie [France] ; Jeffrey Szer [Australie] ; Martin S. Tallman [États-Unis] ; Daniel J. Weisdorf [États-Unis]

Source :

RBID : PMC:3561424

Abstract

The optimal post-remission treatment for acute myeloid leukemia in first complete remission remains uncertain. Previous comparisons of autologous versus allogeneic hematopoietic cell transplantation noted higher relapse, but lower treatment-related mortality though using bone marrow grafts, with treatment-related mortality of 12-20%. Recognizing lower treatment-related mortality using autologous peripheral blood grafts, in an analysis of registry data from the Center for International Blood and Transplant Research, we compared treatment-related mortality, relapse, leukemia-free survival, and overall survival for patients with acute myeloid leukemia in first complete remission (median ages 36-44, range 19-60) receiving myeloablative HLA-matched sibling donor grafts (bone marrow, n=475 or peripheral blood, n=428) versus autologous peripheral blood (n=230). The 5-year cumulative incidence of treatment-related mortality was 19% (95% confidence interval, 16-23%), 20% (17-24%) and 8% (5-12%) for allogeneic bone marrow, allogeneic peripheral blood and autologous peripheral blood stem cell transplant recipients, respectively. The corresponding figures for 5-year cumulative incidence of relapse were 20% (17-24%), 26% (21-30%) and 45% (38-52%), respectively. At 5 years, leukemia-free survival and overall survival rates were similar: allogeneic bone marrow 61% (56-65%) and 64% (59-68%); allogeneic peripheral blood 54% (49-59%) and 59% (54-64%); autologous peripheral blood 47% (40-54%) and 54% (47-60%); P=0.13 and P=0.19, respectively. In multivariate analysis the incidence of treatment-related mortality was lower after autologous peripheral blood transplantation than after allogeneic bone marrow/peripheral blood transplants [relative risk 0.37 (0.20-0.69); P=0.001], but treatment failure (death or relapse) after autologous peripheral blood was significantly more likely [relative risk 1.32 (1.06-1.64); P=0.011]. The 5-year overall survival, however, was similar in patients who received autologous peripheral blood (n=230) [relative risk 1.23 (0.98-1.55); P=0.071] or allogeneic bone marrow/peripheral blood (n=903). In the absence of an HLA-matched sibling donor, autologous peripheral blood may provide acceptable alternative post-remission therapy for patients with acute myeloid leukemia in first complete remission.


Url:
DOI: 10.3324/haematol.2012.062059
PubMed: 22983587
PubMed Central: 3561424


Affiliations:

Links toward previous steps (curation, corpus...)

Le document en format XML

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HLA-identical sibling transplantation for acute myeloid leukemia in first complete remission: a registry study from the Center for International Blood and Marrow Transplantation Research</title>
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<name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I." last="Marks">David I. Marks</name>
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<nlm:aff id="af12-0980185">Bristol Children's Hospital, Bristol, UK</nlm:aff>
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<name sortKey="Nabhan, Chadi" sort="Nabhan, Chadi" uniqKey="Nabhan C" first="Chadi" last="Nabhan">Chadi Nabhan</name>
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<nlm:aff id="af15-0980185">Hopital Saint Louis, Paris, France</nlm:aff>
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<name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name>
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<name sortKey="Tallman, Martin S" sort="Tallman, Martin S" uniqKey="Tallman M" first="Martin S." last="Tallman">Martin S. Tallman</name>
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<title xml:lang="en" level="a" type="main">Autologous blood cell transplantation
<italic>versus</italic>
HLA-identical sibling transplantation for acute myeloid leukemia in first complete remission: a registry study from the Center for International Blood and Marrow Transplantation Research</title>
<author>
<name sortKey="Keating, Armand" sort="Keating, Armand" uniqKey="Keating A" first="Armand" last="Keating">Armand Keating</name>
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<nlm:aff id="af1-0980185">Princess Margaret Hospital, University of Toronto, Ontario, Canada</nlm:aff>
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<name sortKey="Dasilva, Gisela" sort="Dasilva, Gisela" uniqKey="Dasilva G" first="Gisela" last="Dasilva">Gisela Dasilva</name>
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<name sortKey="Perez, Waleska S" sort="Perez, Waleska S" uniqKey="Perez W" first="Waleska S." last="Pérez">Waleska S. Pérez</name>
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<country xml:lang="fr">États-Unis</country>
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<name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name>
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<name sortKey="Ballen, Karen K" sort="Ballen, Karen K" uniqKey="Ballen K" first="Karen K." last="Ballen">Karen K. Ballen</name>
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<wicri:regionArea>Massachusetts General Hospital, Boston, MA</wicri:regionArea>
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<name sortKey="Cairo, Mitchell S" sort="Cairo, Mitchell S" uniqKey="Cairo M" first="Mitchell S." last="Cairo">Mitchell S. Cairo</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>New York Medical College, Valhalla, NY</wicri:regionArea>
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<region type="state">État de New York</region>
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<name sortKey="Camitta, Bruce M" sort="Camitta, Bruce M" uniqKey="Camitta B" first="Bruce M." last="Camitta">Bruce M. Camitta</name>
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<nlm:aff id="af7-0980185">Children's Hospital of Wisconsin, Milwaukee, WI, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<name sortKey="Champlin, Richard E" sort="Champlin, Richard E" uniqKey="Champlin R" first="Richard E." last="Champlin">Richard E. Champlin</name>
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<country xml:lang="fr">États-Unis</country>
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<placeName>
<region type="state">Texas</region>
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<name sortKey="Gajewski, James L" sort="Gajewski, James L" uniqKey="Gajewski J" first="James L." last="Gajewski">James L. Gajewski</name>
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<nlm:aff id="af9-0980185">Oregon Health and Science University, Portland, OR, USA</nlm:aff>
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<placeName>
<region type="state">Oregon</region>
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<name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M." last="Lazarus">Hillard M. Lazarus</name>
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<nlm:aff id="af10-0980185">University Hospitals Case Medical Center, Cleveland, OH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<placeName>
<region type="state">Ohio</region>
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<name sortKey="Lill, Michael" sort="Lill, Michael" uniqKey="Lill M" first="Michael" last="Lill">Michael Lill</name>
<affiliation wicri:level="2">
<nlm:aff id="af11-0980185">Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cedars-Sinai Medical Center, Los Angeles, CA</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
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<name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I." last="Marks">David I. Marks</name>
<affiliation wicri:level="1">
<nlm:aff id="af12-0980185">Bristol Children's Hospital, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Bristol Children's Hospital, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
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<name sortKey="Nabhan, Chadi" sort="Nabhan, Chadi" uniqKey="Nabhan C" first="Chadi" last="Nabhan">Chadi Nabhan</name>
<affiliation wicri:level="2">
<nlm:aff id="af13-0980185">Advocate Lutheran General Hospital, Park Ridge, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Advocate Lutheran General Hospital, Park Ridge, IL</wicri:regionArea>
<placeName>
<region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
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<name sortKey="Schiller, Gary J" sort="Schiller, Gary J" uniqKey="Schiller G" first="Gary J." last="Schiller">Gary J. Schiller</name>
<affiliation wicri:level="2">
<nlm:aff id="af14-0980185">UCLA Center for Health Sciences, Los Angeles, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>UCLA Center for Health Sciences, Los Angeles, CA</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Socie, Gerald" sort="Socie, Gerald" uniqKey="Socie G" first="Gerald" last="Socie">Gerald Socie</name>
<affiliation wicri:level="3">
<nlm:aff id="af15-0980185">Hopital Saint Louis, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hopital Saint Louis, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name>
<affiliation wicri:level="1">
<nlm:aff id="af16-0980185">Royal Melbourne Hospital City Campus, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Royal Melbourne Hospital City Campus, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Tallman, Martin S" sort="Tallman, Martin S" uniqKey="Tallman M" first="Martin S." last="Tallman">Martin S. Tallman</name>
<affiliation wicri:level="2">
<nlm:aff id="af17-0980185">Memorial Sloan Kettering Cancer Center, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Memorial Sloan Kettering Cancer Center, New York, NY</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name>
<affiliation wicri:level="2">
<nlm:aff id="af18-0980185">University of Minnesota Medical Center, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Minnesota Medical Center, Minneapolis, MN</wicri:regionArea>
<placeName>
<region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Haematologica</title>
<idno type="ISSN">0390-6078</idno>
<idno type="eISSN">1592-8721</idno>
<imprint>
<date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>The optimal post-remission treatment for acute myeloid leukemia in first complete remission remains uncertain. Previous comparisons of autologous
<italic>versus</italic>
allogeneic hematopoietic cell transplantation noted higher relapse, but lower treatment-related mortality though using bone marrow grafts, with treatment-related mortality of 12-20%. Recognizing lower treatment-related mortality using autologous peripheral blood grafts, in an analysis of registry data from the Center for International Blood and Transplant Research, we compared treatment-related mortality, relapse, leukemia-free survival, and overall survival for patients with acute myeloid leukemia in first complete remission (median ages 36-44, range 19-60) receiving myeloablative HLA-matched sibling donor grafts (bone marrow, n=475 or peripheral blood, n=428)
<italic>versus</italic>
autologous peripheral blood (n=230). The 5-year cumulative incidence of treatment-related mortality was 19% (95% confidence interval, 16-23%), 20% (17-24%) and 8% (5-12%) for allogeneic bone marrow, allogeneic peripheral blood and autologous peripheral blood stem cell transplant recipients, respectively. The corresponding figures for 5-year cumulative incidence of relapse were 20% (17-24%), 26% (21-30%) and 45% (38-52%), respectively. At 5 years, leukemia-free survival and overall survival rates were similar: allogeneic bone marrow 61% (56-65%) and 64% (59-68%); allogeneic peripheral blood 54% (49-59%) and 59% (54-64%); autologous peripheral blood 47% (40-54%) and 54% (47-60%);
<italic>P</italic>
=0.13 and
<italic>P</italic>
=0.19, respectively. In multivariate analysis the incidence of treatment-related mortality was lower after autologous peripheral blood transplantation than after allogeneic bone marrow/peripheral blood transplants [relative risk 0.37 (0.20-0.69);
<italic>P</italic>
=0.001], but treatment failure (death or relapse) after autologous peripheral blood was significantly more likely [relative risk 1.32 (1.06-1.64);
<italic>P</italic>
=0.011]. The 5-year overall survival, however, was similar in patients who received autologous peripheral blood (n=230) [relative risk 1.23 (0.98-1.55);
<italic>P</italic>
=0.071] or allogeneic bone marrow/peripheral blood (n=903). In the absence of an HLA-matched sibling donor, autologous peripheral blood may provide acceptable alternative post-remission therapy for patients with acute myeloid leukemia in first complete remission.</p>
</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Australie</li>
<li>Brésil</li>
<li>Canada</li>
<li>France</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region>
<li>Californie</li>
<li>Illinois</li>
<li>Massachusetts</li>
<li>Minnesota</li>
<li>Ohio</li>
<li>Ontario</li>
<li>Oregon</li>
<li>Texas</li>
<li>Wisconsin</li>
<li>État de New York</li>
<li>État de São Paulo</li>
<li>Île-de-France</li>
</region>
<settlement>
<li>Paris</li>
<li>São Paulo</li>
<li>Toronto</li>
</settlement>
<orgName>
<li>Université de Toronto</li>
</orgName>
</list>
<tree>
<country name="Canada">
<region name="Ontario">
<name sortKey="Keating, Armand" sort="Keating, Armand" uniqKey="Keating A" first="Armand" last="Keating">Armand Keating</name>
</region>
<name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name>
</country>
<country name="Brésil">
<region name="État de São Paulo">
<name sortKey="Dasilva, Gisela" sort="Dasilva, Gisela" uniqKey="Dasilva G" first="Gisela" last="Dasilva">Gisela Dasilva</name>
</region>
</country>
<country name="États-Unis">
<region name="Wisconsin">
<name sortKey="Perez, Waleska S" sort="Perez, Waleska S" uniqKey="Perez W" first="Waleska S." last="Pérez">Waleska S. Pérez</name>
</region>
<name sortKey="Ballen, Karen K" sort="Ballen, Karen K" uniqKey="Ballen K" first="Karen K." last="Ballen">Karen K. Ballen</name>
<name sortKey="Cairo, Mitchell S" sort="Cairo, Mitchell S" uniqKey="Cairo M" first="Mitchell S." last="Cairo">Mitchell S. Cairo</name>
<name sortKey="Camitta, Bruce M" sort="Camitta, Bruce M" uniqKey="Camitta B" first="Bruce M." last="Camitta">Bruce M. Camitta</name>
<name sortKey="Champlin, Richard E" sort="Champlin, Richard E" uniqKey="Champlin R" first="Richard E." last="Champlin">Richard E. Champlin</name>
<name sortKey="Cutler, Corey S" sort="Cutler, Corey S" uniqKey="Cutler C" first="Corey S." last="Cutler">Corey S. Cutler</name>
<name sortKey="Gajewski, James L" sort="Gajewski, James L" uniqKey="Gajewski J" first="James L." last="Gajewski">James L. Gajewski</name>
<name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M." last="Lazarus">Hillard M. Lazarus</name>
<name sortKey="Lill, Michael" sort="Lill, Michael" uniqKey="Lill M" first="Michael" last="Lill">Michael Lill</name>
<name sortKey="Nabhan, Chadi" sort="Nabhan, Chadi" uniqKey="Nabhan C" first="Chadi" last="Nabhan">Chadi Nabhan</name>
<name sortKey="Schiller, Gary J" sort="Schiller, Gary J" uniqKey="Schiller G" first="Gary J." last="Schiller">Gary J. Schiller</name>
<name sortKey="Tallman, Martin S" sort="Tallman, Martin S" uniqKey="Tallman M" first="Martin S." last="Tallman">Martin S. Tallman</name>
<name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name>
</country>
<country name="Royaume-Uni">
<noRegion>
<name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I." last="Marks">David I. Marks</name>
</noRegion>
</country>
<country name="France">
<region name="Île-de-France">
<name sortKey="Socie, Gerald" sort="Socie, Gerald" uniqKey="Socie G" first="Gerald" last="Socie">Gerald Socie</name>
</region>
</country>
<country name="Australie">
<noRegion>
<name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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